Dudchenko I. The clinical significance of beta1-adrenoceptor gene polymorphism and the alfa-subunit of G-protein in patients with hypertension, combined with nutritional obesity.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U003655

Thesis Registration Form

0415U003655.pdf

Applicant for

Specialization

  • 14.01.02 - Внутрішні хвороби

04-06-2015

Specialized Academic Board

Д 26.003.08

Essay

The dissertation is proved that the presence of a combination of genotypes Arg389Arg/Arg389Gly/T393T associated with a higher risk for hypertension,a higher heart rate, systolic blood pressure levels among patients with hypertension combined with overweight and obesity than the combined genotypes Gly389Gly/T393C/C393C. Studies new approaches to the treatment of hypertension beta-blockers depending on T393C polymorphism gene alfa-subunit of G-protein and Arg389Gly gene polymorphism beta1-adrenergic receptors, since the combination of genotypes Arg389Arg/Arg389Gly/T393T patients with obesity ofen reach the "target" of blood pressure, there is substantial decrease in heart rate and systolic blood pressure than the combined Gly389Gly/T393C/C393C genotypes.

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Автореферат Дудченко І.О.docx

Дисертація Дудченко І.О.docx

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