Morozov O. The influence of physical activity on the course of type 1 diabetes and substantiation planning of physical load in pediatric patients.

Research object: type 1 diabetes mellitus (DM) in children. Objective: to substantiate the measures for improving the effectiveness of treating children with type 1diabetes by optimizing physical activity (PA), aimed at preventing vascular complications and metabolic disorders. Methods: clinical and instrumental, biochemical, spectrophotometric; immunoenzymic; questioning (filling in the forms), pedometria, and statistical. Results: new data on the character of general physical activities have been obtained while carrying out our study in children with the disease. The study has also verified the data regarding the positive impact of a high level of PA on the state of metabolic compensation of the disease and an oxidative imbalance decrease (inhibition of peroxidation and improvement of antioxidant defense), but only under conditions of the diabetes optimal glycemic control. Some new data have been obtained on a decrease of vascular endothelial growth factor (VEGF) production in children with DM, associated with diabetes metabolic decompensation, especially with dyslipidemia than dysglycemia. Proved Dependence of the nature of metabolic deviations and reactions of the cardiovascular system on the dosed physical load has been proved to be related with the initial level of PA in children with type 1 DM. A modified questionnaire has been worked out to assess PA level in children with type 1 DM. The results obtained as regards the impact of PA on the course of type 1diabetes make it possible to single out the groups of patients with an increased risk of hypoglycemic states and metabolic disorders (male patients and patients with a low or unsatisfactory compensation of the disease). The results of the study have been introduced into practical work of endocrinologists, pediatricians, general practitioners/family doctors in medical institutions of Kharkiv.