Pryimenko N. Optimization of preventive measures in case of grippe for patients with Arg753Gln TLR-2, Leu412Phe TLR-3, Asp299Gly TLR-4 genes polymorphisms

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0415U004626

Thesis Registration Form

0415U004626.pdf

Applicant for

Specialization

  • 14.01.13 - Інфекційні хвороби

28-09-2015

Specialized Academic Board

Д 26.614.01

State Institution "The L.V. Gromashevsky Institute of epidemiology and infectious diseases of NAMS” of Ukraine"

Essay

In the thesis on the basis of clinical and anamnestic examination and the study of the prevalence of polymorphisms of genes Arg573Gln TLR-2, Leu412Phe TLR-3, Asp299Gly TLR-4, it has been established that persons with polymorphically changed genotypes have an increased susceptibility to inflammatory diseases of the upper and lower respiratory tract, frequent ARVIs, severe and complicated course of grippe and grippe-associated pneumonia, while the effectiveness of grippe vaccination is determined at a rate of the vaccinated patients with normal distribution of gene alleles according to the immune and clinical-epidemiological parameters.

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Files

aref.doc

dis.doc

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