Rozhko O. Prevention of dental caries in children with hypothyroidism

In the dissertation work a theoretical and experimental study of the prevention and treatment of major dental diseases in children with diffuse nontoxic goiter, in which the prevalence and intensity of caries is significantly higher than the average in Ukraine and in healthy children.The use in experiments on combined model of caries and hypothyroidism developed therapeutic and preventive complex allowed to normalize in animals the basic biochemical parameters of teeth pulp and alveolar process bone. The use of therapeutic and preventive complex allowed for 2 years to get the observations in children with diffuse non caries preventive efficacy of 40-50 %. At the same time they have significantly improved periodontal indices, indicators of the level of oral hygiene. In oral liquid increased levels of calcium, phosphorus, catalase activity, 5 times - prooxidant antioxidant index, in 3 times - lysozyme activity and decreased MDA content, elastase activity and urease, decreased pH fluctuations in some samples, improved indicators TER test teeth, reducing the electrical conductivity of the enamel of the teeth, improve the microcapillary bed gums and barrier protection.