Syrma O. Morphological changes in skin tissues of rats under conditions of intradermal administration of silver nanoparticles of different size

This thesis is devoted to studying the features of the morphological changes of the rat skin with intradermal administration of 20, 30, 70 nm silver nanoparticles. Size-dependent effects of silver nanoparticles were identified, depending on the nanoparticles size recovery rate of basement membrane structure differs (the fastest - under conditions of 30 nm silver nanoparticles influence, under conditions of 20 nm silver nanoparticles influence, regeneration was absent); the increase of mitotic index of the epidermal basal cells (the highest under conditions of 30 nm silver nanoparticles influence); changes of dermal fibroblasts's heteromorphism, such as increasing of number of functionally active fibroblasts (the highest under the conditions of 30 nm silver nanoparticles influence); and the number of collagen fibers of the dermis (the highest under conditions of 30 nm silver nanoparticles influence).