Zborovska O. Pathogenic mechanisms of formation and hemodynamic disorders pharmacotherapy in children with congenital heart disease after surgical correction

The dissertation is devoted to study hemodynamic disorders in children with congenital heart disease (CHD) after surgical correction based on the definition of their nature and structure of myocardial dysfunction by tissue doppler and determine the role of galektyne-3 in pathogenetic mechanisms of it's formation. We proved that (72,28-76,63) % of children with the CHD has been a decline in the longitudinal contractility of the left and right ventricles, respectively. Tissue doppler indicators ahead of time other indicators of global myocardial disorders. Analysis of galektyne-3 level in the serum showed a significant increase in it's 1,36-2,02 times for all types of hemodynamic CHD, especially when depletion and circulatory system as the progression of heart failure. Given the results of the study suggested a differentiated approach to drug correction of myocardial dysfunction in children, depending on the type of hemodynamic defects.