Koval O. Prognostic significance of toxic metals and metalloids in the formation of congenital heart diseases in children.

The dissertation is devoted to the problem of the rise of prognosis efficiency of cardiofascular malformayions formation of fetus by determining the presence and concentration of toxic metals in heart and great vessels tissue of children with cardiogenesis violation. The greatest number of toxic metals in pathological concentrations was found in fetuses and newborns in comparation to children older than one year of age, that could determine their possible role in etiopathogenesis of cardiogenesis violation. Results of this investigation defined the wolfram, lithium, arsenic, nickel, tin, lead, silver, strontium, titanium concentrations, which determines the risk of malformations of the heart and great vessels. Scientifically grounded the method of toxic substances pathological concentration score in cardiovascular tissue, which is determine the presence and concentration of toxic substances in hair and urine. During pregnancy planning process is recommended to identify toxic metals content and concentration in hair of potential parents and lithium, nickel, titanium - in urine. Pathological concentration of these toxic substances indicate the presence of the risk of CHD formation in the fetus. In the hair and urine of the child with CHD is necessary investigate the presence and concentration of toxic substances and decide the volume of further detoxication. We recommend to analyze barium, nickel, lithium and strontium content in patients with simple heart defects; aluminum, arsenic, barium, nickel, lithium, strontium, tin, titanium - of children with combined defects. It is needed research tungsten, silver, titanium, aluminum, nickel, lithium, strontium content in hair and urine of patients with aorta coarctation.