Tkacheva T. Mechanisms of interaction of complexes based on inorganic nanoparticles and organic molecules with model membranes and living cells

Object of investigation: mechanisms of interaction of complexes based on inorganic and organic nanocarriers with model membranes and rat hepatocytes, the interaction between the organic molecules and inorganic nanocarriers. Aim of work: establishment of mechanisms of interaction of complexes based on inorganic nanoparticles ReVO4:Eu3+ and CeO2, and polymethine dyes with model membranes and living cells. Methods of investigation: spectrophotometry, fluorescence spectroscopy and fluorescence excitation spectroscopy, fluorescence microscopy and microspectroscopy, transmission electron microscopy, the method of phase analysis light scattering. Scientific novelty: data of the interaction of organic and inorganic nanocontainers with living cell membrane has been obtained. They can be used to develop new nanoscale hybrid materials for biomedical applications. Fluorescent methods for estimating the thermodynamic and kinetic parameters of complex formation have been proposed. Practical meaning: application in molecular biophysics, molecular biology, pharmacology and biotechnology.