Repich H. Synthesis, structure and spectral characteristics of Fe(III), Co(II), Ni(II), Cu(II), Pd(II), Pt(II), Ag(I) with thiourea, hydrazone and thiosemicarbazone derivatives

Optimal synthesis methods were found and 22 novel complex compounds were obtained in solid state. Structures of all obtained compounds were investigated by single-crystal X-ray diffraction method which correlate with UV-Vis, IR, NMR 1H, 13C, XPS spectroscopy and MALDI-TOF spectrometry data. The influence of starting metal salts, synthesis conditions (pH, solvent, concentration, and stoichiometry of reagents) and presence of additional donor groups in ligand molecules for their coordination mode and formation of different types of complex compounds were investigated. The study of cytotoxic and cytostatic activity of n,??chelate complexes of Pd(II), Pt(II) on HeLa cell culture "in vitro" and also their ability to bind DNA molecules on the model of pUC19 plasmid DNA were performed. All analyzed compounds showed high cytotoxic and cytostatic effect and high ability to binding and cleavage of DNA.