Kaluzhyna O. Pathological anatomy of pulmonary artery and aorta in fetuses and newborns from mothers with complicated pregnancies

It has been found as a result of the research that maternal preeclampsia causes morphofunctional state changes of the pulmonary artery and aorta of fetuses and newborns, manifested in the formation and strengthening of sclerotic processes in endothelial basement membranes, in the middle and outer membranes; violation of endothelial cells trophic with subsequent desquamation; density reduction of smooth myocytes location in view; density increase of CD16 cells location. It has been determined that preeclampsia leads to increase of relative volumes of collagen fibers but not elastic ones in the wall of investigated blood vessels, as in chronic intrauterine hypoxia. Different severity degrees of preeclampsia appears in increase of optical density luminescence of collagen III and I types in media and adventitia of the pulmonary artery and aorta, whereas the oxygen deficiency cases increase of optical density luminescence only of more mature type I collagen on the background of optical density luminescence decrease of collagen type III. Analysis of archival material has shown downward tendency of preeclampsia occurrence from year to year (2006-2010) and existence of extragenital, genital pathologies and their combination, certain age (18-25 years) among risk factors for preeclampsia development. The obtained results make it possible to prove the necessity of separation of children from mothers with pregnancy complicated by preeclampsia and intrauterine chronic hypoxia in risk groups according to vascular pathology development.