Luchinskaya I. Peculiarities of the course and сlinical and laboratory reasoning of prevention of the major dental diseases in children with dismetabolic kidney diseases residing in ecologically unfavorable areas

Object - peculiarities of the motion, prevention and treatment of dental caries and periodontal tissue diseases in children with dismetabolic nephropathy; goal - improving the efficiency of prevention of dental caries and periodontal tissue diseases in children with dismetabolic kidney diseases living in ecologically unfavorable regions by clinical and laboratory study of prevention schemes and evaluation of their efficiency; methods - general clinical, biochemical, ELISA, instrumental, molecular-genetic, medical-statistic; novelty - it was refined data on peculiarities of mineral metabolism in children with dental diseases in combination with dismetabolic nephropathy considering the influence of hormonal regulation of calcium and it's excretion with urine daily; it was first learned individual sensitivity in children with dental diseases and dismetabolic nephropathy to the action of xenobiotics on the basis of research of enzymes activity involved in the process of biotransformation, and the genes that encode their production; results - scientifically grounded direction and extent of treatment and prevention of dental diseases in children with dismetabolic nephropathy; implemened - in treatment and studying process; branch - dentistry