Khlystun N. Pathogenetic substantiation of treatment of chronic catarrhal gingivitis by hyaluronic acid and quercetin (experimentally and clinically research).

The thesis is dedictated to increasing the effectiveness of treatment of chronic catarrhal gingivitis. In the given paper for the first time in the conditions of experimental simulation of periodontal pathologies in rats the effect of hyaluronic acid, quercetin, and their combinations are studied at the levels of biochemical markers of inflammation and amount of hyaluronic acid in the periodontal tissues. Scientific data on changes in biochemical markers of inflammation and count of hyaluronic acid in periodontal tissues are expanded and complemented depending on the external pathogens and the time of their exposure. In various experimental models of gingivitis the possibility and efficacy of parallel use of hyaluronic acid and quercetin in complex treatment of chronic catarrhal gingivitis are demonstrated. The possibility and effectiveness of usage of combined therapeutic action of hyaluronic acid and quercetin in clinical conditions are established that is proved by a decrease in elastase activity by 34.5%, maloni dialdegydi - 30%, urease - 62%, the degree of dysbiosis - by 81.5%, an increase in activity lysozyme - 100%, catalase - by 46.1%, index prooxydanty-antioxydanty - by 108.6% in the oral fluid of patients.