Efremova O. Substantiation of prevention of major dental diseases in the chemical industry (clinical and experimental study)

Workers of chemical production were examined. The intensity of caries in 20-40 years was 2 times higher, complications - 5.5 times higher, and the rate of pathological pockets - 26 times higher than the average rate in Ukraine. With increasing length of working time in the chemical industry was primarily observed violation of bone structure, but not its mineralization. In addition, 100% were observed abnormalities in the genes of the second phase of detoxification NAT2 (S481T) and gene CTR (C1377T), included in the gene network of bone metabolism, which should be considered in development of therapeutic and prophylactic complex. In an experiment on rats in conditions of excess revenues of lipid peroxides with food high efficiency therapeutic and prophylactic complex, which consists of adaptogens, vitamins, minerals and high-quality protein. Designed therapeutic and preventive complex improve dental status, normalized biochemical parameters of oral liquid, blood serum, the charge state of buccal epithelium cells, the functional state of the micro capillary bed gums and barrier protection against microbial factor in the main group of workers.