Tsyganova I. Rationale for autologous osteoplastic biomaterials in the treatment of patients with chronic generalized periodontitis

During experimental studies investigated transport properties osteoplastic material as scaffold for cell culture, a comparative analysis of the process of healing bone defects of the rabbit jaw in the application of osteoplastic materials with the addition of autologous stem cells from bone marrow. Proved and experimentally confirmed the possibility of using autologous stem cells from bone marrow and adipose tissue to optimize the regeneration of bone tissue. Standing dose-dependent effect of stem cells from bone marrow and adipose tissue reduction processes in bone of the lower jaw, the optimal dose was 500 thousand. Stem cells per volume of 0.027 cm3 defect. It has been shown that administration of 500 thousand. stem cells from bone marrow to Collapan 90 days results in histological structure defect restoration of mandibular. Clinical observation group consisted of 20 patients with generalized periodontitis II and III, which conducted a comprehensive treatment. In the study group of 10 patients with stage surgical treatment during the scrappy operations to stimulate bone formation using stem cells, 10 patients of the control group performed a similar patchwork operation without the use of stem cells. The established evidence suggests that the use of autologous stem cells in the surgical phase of complex treatment of periodontal disease has clear advantages over traditional surgical methods of treatment of these diseases, as there is restoration of the structure periodontal pocket removed, installed prolonged remission.