Shekhovtsova Y. The role of apelin-36 and tumor factor necrosis-? in the development of chronic pancreatitis in patients with type 2 diabetes mellitus.

Dissertation is devoted to optimization of diagnostics and prognosis of activation of immune inflammation and structural functional pancreatic disorders in patients with combined course of chronic pancreatitis and type 2 diabetes mellitus on the basis of studying clinical and phenotypic features of their current, level of apelin-36, tumor necrosis factor-?, parameters of carbohydrate and lipid metabolism in conjunction with remodeling of the pancreas. Patients with chronic pancreatitis were characterized by increased apelin-36 and tumor necrosis factor-? activity. Patients with combined course of chronic pancreatitis and type 2 diabetes mellitus were characterized by maximum increased apelin-36 and tumor necrosis factor-? activity. Pathogenetic influence of apelin-36 and tumor necrosis factor-? on the development of structural and functional disorders of the pancreas is determined in patients with chronic pancreatitis. Patients with combined course of chronic pancreatitis and type 2 diabetes mellitus are characterized the most dense relations between deterioration of carbohydrate metabolism and the development of structural and function reorganization of the pancreas. Effect of level apelin-36 and tumor necrosis factor-? on parameters of carbohydrate and lipid metabolism, as well as the remodeling of the pancreas is observed in this group of patients.