Gura E. Special feature of remodeling of myocardium and endothelial disfunction in patients with arterial hypertension and diabetes mellitus and their drug correction.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U001696

Applicant for

Specialization

  • 14.01.02 - Внутрішні хвороби

10-03-2016

Specialized Academic Board

К17.613.02

Essay

The object of study: Patients with essential hypertension stage II 2nd and 3rd degree in combination with type 2 diabetes mellitus. Objective: To increase the effectiveness of treatment and diagnosis of patients with hypertension combined with diabetes type 2 on the basis of studying the characteristics of left ventricular remodeling and vascular endothelial function and their changes under the influence of complex medical correction. Methods: clinical, laboratory, electrocardiographic, echocardiographic, ultrasound, immunological, statistics. Novelty: hypertension combined with diabetes characterized by more unfavorable course, which was manifested in the worse indicators characterizing the endothelial function and intracardiac hemodynamics, level of endothelin-1, nitric oxide metabolites and endothelial-dependent vasodilation.A direct correlation of endothelial dysfunction on the level of hypertension was established.

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