Zadorozhnii P. Synthesis, transformation and heterocyclization of N-(isothiocyanatoalkyl)carboxamides derivatives

The focus of the dissertation is on the study of new heterocyclizations based on N-(isothiocyanatoalkyl)carboxamides derivatives.The foregoing reagents appeared to be suitable for synthesis of new derivatives of 4H-1,3,5-oxadiazine, 1,3,4-oxadiazole, benzimidazole, benzoxazole and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole. It was established how the presence of the trichlormethyl group in the ?-position of alkaloid moiety and the active group in the ortho position of the aryl residue of thioureide moiety affects the passage of the transformations. Corresponding N-hetaryl-2,2-dichloracetamidines were obtained based on the synthesized N-amidoalkylation derivatives of 1,3,4-oxadiazole, 1H-benzimidazole, 1,3-benzoxazole. It is necessary to search bioregulators of diverse action among synthesized compounds.