Kulyk L. Synthesis and properties of biologically active polyurethane ureas containing folate-derivative of ferrocene

The object of the research was the development of biologically active polymer materials for medical purposes. The aim was the synthesis of biologically active polyurethane ureas containing folate-derivative of ferrocene and investigation of their properties and biological activity. The main results were obtained by using the following methods: infrared spectroscopy, proton and carbon nuclear magnetic resonance, elemental analysis, viscometry, differential scanning calorimetry, thermogravimetric analysis, X-ray scattering method, the method of tissue culture, sanitary-chemical and histological methods, spectrophotometric method for glutamat dehidrogenaza activity determining. Scientific novelty of the results obtained consist offered method of chemical modification of polyuretane ureas based on diisocyanate prepolymer and diamines (aliphatic or aromatic), with folate-derivative of ferrocene at the polymer forming stage. The correlation between the content of folate-derivative of ferrocene in polymer, chain extender structure and properties of synthesized polyuretane ureas was established. For the first time, it was shown that the modification of the polymer matrix with 0.5 wt. % of folate-derivative of ferrocene led to the fact that the polymer became biologically active. It was found, that polyuretane ureas samples containing folate-derivative of ferrocene were bioactive and biocompatible materials that can be recommended for clinical studies and potential medical application as coatings for wounds and burns treatment.