Bratus V. Optimization of diagnosis and treatment of patients with silicosis in combination with coronary artery disease on the base of evaluation of neurohumoral regulation processes.

The dissertation is dedicated to optimization of diagnosis and treatment of patients with silicosis in combination with coronary artery disease basing on evaluation of disturbances in processes of neurohumoral regulation, nitric oxide system function and also introduction of morpholinium thiazotate and quercetin.In the dynamics of silicosis with coronary artery disease progression an activation of sympathoadrenal and hypophysis-adrenal systems with depression of seronotoninergic and hypophysis-thyreoid systems, start of intracellular and membrane mechanisms of stress due to intensification of free-radical processes on the background of antioxidant potential exhaust, decrease of nitric oxide bioavailability and generation of its final products -nitrites/nitrates. The revealed disturbances in the processes of neurohumoral regulation and nitric oxide system will allow to substantiate the therapeutic measures for their correction. The use of morpholinium thiazotate and quercetin as metabolic means on the background of traditional treatment scheme for comorbid pathology enhances the efficacy of correction of revealed changes. This is proved by more expressed positive dynamics of clinical data, parameters of sympathoadrenal (urine level of adrenalin, N-methylnicotinamide), serotoninergic (dioxyphenylalanin in urine), pituitary-adrenal (cortisol of blood serum) and pituitary-thyreoid (thyroxin of blood serum) systems, oxidative balance (catalase,superoxidedismutase of blood serum) and nitric oxide system (S-nitrosothiol of blood plasma). Administrationofmorpholiniumthiazotateandquercetinincomplexwithtraditionalstandardtreatmentonasearlyaspossibleearlystageofpulmonaryfibrosisdevelopment and coronary artery disease makes it possible to slowen the progression of this pathology and development of its complications.