Iosyk I. Clinical and pathogenetic features of acute respiratory infections, optimization of diagnostics and therapy.

The thesis presents the results of clinical and laboratory examination of 318 patients with influenza and other acute respiratory infection (ARI), including 83 – with the complication of pneumonia. Was compare different capabilities of laboratory techniques. Was proved that polymerase chain reaction most informative then the method fluorescence antibody. Clinical date of patients was demonstrate. Attention was paid to the fact that etiological deciphering the causative agent for clinical data is important. The course of disease depends on pathogen combination. The longer fever, intoxication and catarrhal syndrome were present in patient with pathogen combination. For an objective assessment of acute respiratory infections severity should be determine the content of pro-inflammatory cytokines. Clinical efficacy of yeast ribonucleic acid (nuklex) was proven. Comprehensive treatment of influenza and other acute respiratory infection that included antiviral drug made it possible to significantly improve clinical data, including reducing the duration of fever, intoxication syndrome, coughing, and discharge patients from the hospital more faster. Application of nuklex contributed to the eradication of influenza and other ARI. Also found enterosorbent effectiveness of silicone paste (paste of enterosgel) in the complex treatment of patients with influenza and other acute respiratory infection. Enterosorbent marked a significant impact on reducing the length (2 times more) intoxication and catarrhal syndromes. Was noted the significant effect of this therapy on shortening the duration of intoxication and catarrhal syndrome. Due to this therapy endogenous intoxication data decreased.