Shandyba S. Features of reconstructive-regenerative interventions in generalized periodontitis in patients with diabetes mellitus type 2.

Dissertation is devoted to the solution of actual theoretical and practical problems - recovery periodontal bone defects in the treatment of generalized periodontitis in patients with diabetes mellitus type 2 by conducting a comprehensive medical and surgical treatment with the targeted regeneration of bone tissue. It has been examined and treated 62 patients with generalized periodontitis with diabetes mellitus type 2. It was proved that the key factors of development, progressive generalized periodontitis in patients with diabetes are persistent and pronounced changes in cellular and humoral immunity, hypercytokinemia the imbalance of pro-inflammatory and anti-inflammatory cytokines and disturbance of bone formation and resorption. It was proved high efficiency of conservative treatment patients and method of surgical reconstructive treatment of generalized periodontitis,that we developed, and involves the use of complex osteoinductive agents (i-PRF, a-PRF and Bio-Oss) and the drug "Likopid" allows for persistent clinical and radiographic remission and full recovery of bone tissue in 84.4% of cases.