Pakhomova V. The content of trace elements in different forms of growth retardation and ways for correcting the revealed disorders

Object of the study: short stature in children and adolescents. Aim of the study: to increase the efficiency of the treatment of various forms of dwarfism, based on a comprehensive study of the content of essential trace elements in the blood and hair in children and adolescents. Methods of the investigation and equipment: clinical, anthropometric, biochemical, radioimmunoassay, immunoassay, spectrometry, genetic tools, statistics; Spectrometer «ElvaX-med», analіzator Immulate 2000. Theoretical and practical results: a significant imbalance of essential trace elements (zinc, selenium, manganese, copper, chromium) in the children's blood and hair is depending on the form of short stature (growth hormone deficiency, biologically syndrome inactive growth hormone, family-constitutional short stature, genetically-caused stunting) which is caused by the disorders of the growth hormone / IGF-I axis, so it is needed to determine the level of compulsory before and during the growrh hormone therapy. It is shown the lack of one or several trace elements, primarily of zinc and selenium, in patients with growth hormone deficiency, and that is the basis for prescribing zinc supplementation in combination with growth hormone therapy. Novelty: the data about the content of the trace elements in patients with short stature according to the age, sex and type of dwarfism were obtained for the first time. There is a strong correlation between the increasing of IGF-I and zinc in blood plasma in children with growth hormone deficiency. It was proven a significant effect of adding zinc supplementation to growth hormone therapy due to increase the level of IGF-I in children with growth hormone deficiency. The use of zinc supplementation is effective in the treatment of patients with different forms of growth retardation. Degree of introduction: the results of the study are introduced into the clinical work of the regional hospitals. Posted innovation (KPKV 6561040). The patents №71055, 72818. Field of application: endocrinology.