Kucher O. Enantioselective enzymatic resolution of 1-cycloalkyl(aryl, hetaryl)etanols

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U005295

Thesis Registration Form

0416U005295.pdf

Applicant for

Specialization

  • 02.00.10 - Біоорганічна хімія

30-09-2016

Specialized Academic Board

Д 26.220.01

V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine

Essay

Optically active derivatives of 1-cycloalkyl(aryl, hetaryl)ethanols. Development of preparative method of racemic 1-cycloalkyl(aryl, hetaryl)ethanols resolution using enzymatic catalysis. Organic synthesis, IR-, NMR-spectroscopy, LCMS, X-ray structure analysis, chiral HPLC analysis. Optically pure 1-cyclopropylethanols and 1-cyclobutylethanols were obtained. A method of resolution of chroman-4-ol and its structural analogues with high enantiomeric excess (ее 95%) was developed. New optically pure 2,2,2-trifluoro-1-hetarylethanols were synthesized. Results can find application in organic and bioorganic chemistry.

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Files

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