Tymtsunik A. Synthesis of bicyclic analogs of nipecotic acid.

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0416U005629

Thesis Registration Form

0416U005629.pdf

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

08-12-2016

Specialized Academic Board

Д 26.217.01

Institute of Organic Chemistry NAS of Ukraine

Essay

The thesis is devoted to the design and synthesis of bicyclic analogs of nipecotic acid based on a series of azabicycloalkane scaffolds. A modified Simmons-Smith reaction was used for the construction of the cyclopropane ring. The synthetic application of the reaction was demonstrated by the synthesis of 2,3-methano- -proline (as the N-Boc derivative). A tandem Strecker reaction - intramolecular nucleophilic cyclization sequence was used as the key synthetic step, for the first time to prepare a diamino acid.

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