Hnateyko N. Role of multidimensional bone markers in the diagnosis of disorders consolidation of fractures and principles of prevention

The thesis shows new solution of actual scientific task - improving the efficiency of the treatment results of patients with diaphyseal fractures and principles of prevention of healing of bone fractures by implementing complex therapy and criteria for choice of treatment developed on the basis of identification of new informative metabolic and genetic markers of bone formation, reflecting the tendency the development of complications of bone consolidation in the form of reparative bone disorders. The results showed that predictors of disorders reparative osteogenesis in the consolidation of long bones may include changes in markers of bone formation: the high content of Ca, Mg and inorganic P in serum of patients with high daily excretion of inorganic phosphorus in urine, lack of expected high activity of alkaline phosphatase while increasing acid phosphatase activity, low activity of serum calcitonin with PTH simultaneous high activity and low activity of testosterone and estradiol in the body of patients of both sexes, lowered maintenance TGFB-1. The efficiency of the method of preserving mizhulamkovoyi hematoma regardless of the choice of surgical or conservative approach to treating patients.