Davydenko V. Clinical and morphological state of taste receptors in the period of patients' adaptation to removable laminar dentures.

The thesis considers the study of clinical and morphological state of taste receptors at the early period of patients' adaptation to removable acrylic resin laminar dentures. The findings proved the influence of residual monomer on the emergence of the changes in gustation at the early patients' adaptation to removable acrylic resin laminar dentures, allowing optimization of the diagnostic process of such changes through the analysis of gustation threshold at different terms of the adaptation and creation of the model of taste receptors damage in experimental animals. The device for human tongue taste buds sensitivity detection has been created and proposed for the first time to optimize the diagnostic process in studying the changes in gustation during the patients' adaptation to removable acrylic resin laminar dentures. The device aided in assessment of gustation change during patients' adaptation to full dentures. Application of the proposed device allows reducing the time and dates of study, objectifies and visualizes the resulting evaluation of gustation, enables tracking of dynamics of gustation changes in the process of therapeutic and diagnostic activities. The model of experimental animals' taste receptors damage by the acrylic resin monomer has been created and morphological state of animals' tongue mucosa in different terms of monomer affection has been studied for the first time.