Kotsyuba O. The peculiarities of clinical course of essential arterial hypertension followed by diastolic heart failure with symptom-free hyperuricemia and increasing treatment efficiency under conditions of concomitance.

Dissertation is devoted to increasing treatment efficiency of the hypertensive patients with diastolic heart failure and concomitant hyperuricemia complication by means of differential lisinopril/valsartan and allopurinol with/without L-arginine usage. The peculiarities of arterial hypertension, diastolic heart failure clinical course, NT-proBNP levels, vegetative regulation and lipid and purine disturbances have been studied; correlations between these indexes under conditions of concomitance have been established in hypertensive patients with symptom-free hyperuricemia. The efficiency and differential approach to ACE lisinopril/ARB valsartan usage to correct left ventricle diastolic dysfunction as well as NT-proBNP and uric acid levels in hypertensive patients with symptom-free hyperuricemia and diastolic heart failure have been assessed. The importance of the allopurinol and L-arginine usage in addition to the combined antihypertensive treatment to correct lipid and purine disturbances, left ventricle diastolic dysfunction in hypertensive patients with concomitant hyperuricemia has been proved.