Melnyk O. 5-Alkenyl-functionalized 4-chloroimidazoles and their derivatives

This thesis is devoted to creation methods of synthesis and investigation of chemical transformations of alkenyl-functionalized 4-chloro-1H-imidazoles. Condensation of 5-formyl-4-chloroimidazoles with nitroalkanes and acetophenones developed general synthetic approaches of new imidazole-containing electrophilic reagents - 5-(2-nitrovinyl)-4-chloroimidazoles and 3-(imidazol-5-yl)-1-aryl-2-propen-1-ones. The methods of obtaining synthetically important (4-chloro-1H-imidazole-5-yl)acetic acid and pharmacologically significant 5-(4-chloroimidazol-5-yl)methylene-1,3-thiazolidine-2,4-dione and 4-(4-chloroimidazol-5-yl)-2-aminochromenocarbonitriles was proposed.