Kemskii S. Structural functionalization of pyrazolo[3,4-е][1,4]diazepines

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0417U001485

Thesis Registration Form

0417U001485.pdf

Applicant for

Specialization

  • 02.00.03 - Органічна хімія

16-03-2017

Specialized Academic Board

Д 26.217.01

Institute of Organic Chemistry NAS of Ukraine

Essay

This dissertation aims to develop an efficient and convenient methodology for modification of diazepine scaffold of pyrazolo[3,4-e][1,4]diazepines with acyclic and heterocyclic groups. A one-pot method for the synthesis of previously unknown 7-carboxyalkylthio-5,6,7,8-tetrahydro-1Н-pyrazolo[3,4-e][1,4]diazepin-4-ones from 7-hydroxy derivatives of pyrazolo[3,4-e][1,4]diazepines was developed. A method of obtaining new 4-oxopyrazolo[3,4-e][1,4]diazepin-7-carbonitriles (carboxamides, carboxylic acids) was proposed that requires potassium cyanide as C-nucleophile.

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Files

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