The research based on a complex clinical, psychopathological and diagnostic examination of 186 patients with schizophrenia spectrum disorders F 20 - F 29 to observe influence of environment factors, namely the using of cannabinoids, perinatal complications and psychological injury to the peculiarities of manifestation, course and level of social functioning. It was found that the people with the presence of environment factors observed schizotypal and schizoaffective disorders, whereas individuals without these factors proven suffer from paranoid schizophrenia. The results set the difference of the clinical view and the level of social functioning, and relationship established depending on the impact of various environment factors. Thus, patients which used cannabinoids most often suffer from schizoaffective disorder, the clinical view was manic syndrome with predominance of delusional ideas, hallucinations, agitation, and other psychiatric symptoms such as anxiety, unusual thoughts content, contactless, refusal of cooperation, poor communication, disorientation. It was established correlation between early manifestation of schizophrenia spectrum disorders and the use of cannabinoids. Patients with perinatal complications suffer simple form of schizophrenia, among this category was the highest sum of positive and negative scale, mainly due to negative symptoms, the clinical picture is dominated by stereotypic, violation of abstract thinking, breach of spontaneity, smoothness of speech, disorientation, breach attention. Also, this group showed the lowest levels of social functioning. In patients who were subjected to psychological injury occur schizotypal and schizoaffective disorder with prevalence of paranoid symptoms, where the clinical view of the disease characterized by the idea of greatness, difficulties in communication, violation of abstract thinking, stereotypical thinking, high level of guilt and depression contactless. In the case of psychological trauma, early manifestation occurs 1.3 times more frequently than in patients without the effect of these factors. Thus, the data allowed develop recommendations for primary and secondary prevention of schizophrenia spectrum disorders, taking into account the impact of environment factors on clinical pathology of the disease, which is the formation of specific risk groups and of early psychosocial intervention in order to improve the course of disease and the level of social functioning.
