Yavorovych M. Diagnostic and prognostic significance of endothelial function stateand profibrogenic mediators in children with hemorrhagic vasculitis

The thesis deals with study, improvement, prognosis, course and early diagnosis of hemorrhagic stroke complications in children based on monitoring of monocytic chemotactic protein-1, nitrogen oxide metabolites, Willebrand factor and morphofunctional status of vessels as indices of vasoregulatory function of endothelium. A mathematical model of prognosis of unfavorable course and development of renal syndrome in hemorrhagic vasculitis in children was elaborated with due regard to indices of intima-media complex thickness of the common carotid artery along with assessment of monocytic chemotactic protein-1and Willebrand factor. The impact of MCP-1, NO and Willebrand factor on the course of inflammatory processes of vessel wall, coagulation potential of the blood as well as specific and non-specific body protection factors was proved. Presence of morphological and functional changes of vessels in children with hemorrhagic vasculitis was established according to indices of intima-media complex thickness of the common carotid artery, endothelium-dependent vasodilation of the brachial artery and indices of ultrasonic doplerography of the brachial artery, which are more significant in children with severe form of the disease and mixed form of hemorrhagic with renal syndrome.