Syzova L. Optimization of treatment and diagnostic tactic of chronic hepatitis C in patients with polymorphism Asp299Gly of the TLR4 gene and Gln11Leu of the TLR7 gene

The dissertation investigates ways of an optimization of treatment and diagnostic tactic of chronic hepatitis C (CHC) in patients with polymorphism Asp299Gly of the TLR4 gene and Gln11Leu of the TLR7 gene. Was investigated the prevalence of polymorphism Asp299Gly of the TLR4 gene and Gln11Leu of the TLR7 gene in patients with CHC, were defined risk factors for the development of the disease. Was conducted complex research of clinical and laboratory features and of the rate of fibrosis progression in patients with СНC depending on the presence of the mentioned polymorphisms. Was established a protecting role of "mutant" genotypes Gln11Leu+Leu11Leu and allele 11Leu of the TLR7 gene in the rate of fibrosis progression. Were identified clinical and genetic risk factors for rapidly progressive liver fibrosis in CHC and was created a prognostic model of 6 independent factors that allows calculating the probability of the reference of the patient to the risk group. Was estimated an efficiency of the antiviral therapy of CHC by the pegylated interferon and ribavirin in patients with polymorphism Asp299Gly of the TLR4 gene and Gln11Leu of the TLR7 gene and were defined clinical and genetic predictors of its low efficiency.