Kogan L. Prevention and treatment of periodontal diseases in children previously operated on for congenital cleft lip and palate

The results of the clinical trial supplemented by scientific data on the structure of dental disease in children previously operated on congenital cleft lip and palate, and shows that this category of children aged 7-15 years with chronic catarrhal gingivitis was diagnosed at 94.82 %, hypertrophic gingivitis - at 55.67 %, generalized periodontitis - at 14.30 %. Confirmed scientific evidence that the more severe forms of periodontal lesions observed in children who previously operated on dual cleft upper lip, hard and soft palate. Conducted molecular genetic studies on buccal epithelium cells of children born with dual cleft upper lip, hard and soft palate, discovered gene polymorphism zinc finger protein 533 (ZNF533) 60% of confirming the diagnostic value of determining it during genetic predisposition assess children for congenital malformations of the maxillofacial area. Developed pathogenesis reasonable way to prevent inflammatory periodontal diseases in children who previously were operated for congenital cleft palate, which involves the use of antimicrobial agent local action, mucosal gel and probiotics, and shows that the use of developed set of measures has reduced the intensity of inflammation in periodontal tissues, normalize biochemical indices of oral liquid, improve charge state buccal epithelium cells and functional status micro-capillary bloodstream.