Markina A. Іnteraction of Si- and Al-сontaining enterosorbents with biohydrogel of polysaccharide origine

The thesis deals with the relationship between the structure of the surface of silicon and aluminium containing enterosorbents and their impact on the absorption of substances in the intestine. The physico-chemical characterization of enterosorbents such as nanosilica, enterosgel, kaolin, dioctahedral smectite and fumed alumina is carried out. The use of vitreous body as a model of the mucin layer of the intestine is justified. The interaction of enterosorbents with the components of model biohydrogel such as hyaluronic acid, chondroitin sulfate and protein is studied. By the 1H NMR spectroscopy measurements the state of water in the vitreous body and at interfaces in composites 'SiO2(Al2O3)/vitreous body' are researched. It is stated that diffusion of D-xylose across the hydrogel simulating intestinal mucin layer in the presence of nanosilica, alumina and kaolin is significantly slowed. It can be due to the ability of nanoparticles of sorbents to interact with glycosaminoglycans of hydrogel to form structures that impede the migration of molecules of D-xylose. It is proved that studied enterosorbents in therapeutic doses have no significant effect on the rate of D-xylose absorption from the intestine of rats and mice.