The object of the study is dysplastic (idiopathic) scoliosis in children; the aim is to optimize the diagnostic tactics and the complex of conservative treatment of children with dysplastic scoliosis of I-III degree on the basis of studying changes in the immune system and metabolic processes; methods - clinical, radiological, densitometric, immunological, biochemical, mathematical, statistical; novelty and results - for the first time it was established that the immune response in children with I degree of dysplastic (idiopathic) scoliosis is caused by aseptic inflammation of the cartilaginous tissue and is characterized by increased production of pro-inflammatory IL-1?, activation of nonspecific defense factors and cellular immunity; the necessity of immunocorrection in the complex of treatment of children with primary manifestations of dysplastic (idiopathic) scoliosis is proved; it is established that the progression of the disease (grade II-III of scoliosis) is accompanied by an imbalance of correlation relationships between the indices of cellular and humoral immunity and the development of autoimmune reactions; for the first time it was established that for children with dysplastic (idiopathic) scoliosis, irrespective of the degree, a deficiency of energy metabolites and changes in the electrolyte balance are characteristic, while it is determined that the primary manifestations of spinal deformity in children occur against the background of a low activity of alkaline phosphatase and increased activity of acid phosphatase, progression of the disease is associated with changes in protein metabolism and a deficiency of calcium and magnesium; justified drug therapy of children with dysplastic (idiopathic) scoliosis, taking into account the degree of disease, changes in the state of the immune system and metabolic processes; rational approaches to optimizing the conservative treatment of children with dysplastic (idiopathic) scoliosis are suggested, which contribute to improving the results of treatment - stabilizing or preventing the progression of spine deformity; was introduced into the clinical practice of the Research Institute of Traumatology and Orthopedics of the Donetsk National Medical University of the Ministry of Health of Ukraine, Liman, and the State Institution "Institute of Spine and Joint Pathology named after Prof. M. I. Sitenko of the Academy of Medical Sciences of Ukraine", Kharkov, as well as In the pedagogical process of the Department of Traumatology, Orthopedics and Military Surgery of the Donetsk National Medical University of the Ministry of Health of Ukraine, Liman; the field of application is the treatment and diagnostic process of specialized orthopedic departments, clinics, sanatoriums, scientific and pedagogical processes of the Departments of Traumatology and Orthopedics of Medical Educational Institutions.
