Zanoza S. 4,4'-Disubstituted biphenyls and their analogs. Synthesis, antiviral properties, interferon induction, DNA affinity

Methods of synthesis of 4,4'-dihydroxybiphenyl, benzidine, and 4{(E)-[(4-hydroxyphenyl)imino]methyl}phenol derivatives have been improved, their spectral properties have been studied. Cytotoxicity, antiviral, anti-inflammatory and antibacterial activity, the ability to induce interferon have been examined, and it has been shown that 4,4'-dihydroxybiphenyl derivatives are characterized by low or moderate cytotoxicity, high antiviral activity, titers of interferon usually higher than those induced by a well-known antiviral drug Amiksin, and no anti-inflammatory properties. The inability of 4,4'-dihydroxybiphenyl derivatives to intercalate has been established by spectrofluorometry, spectrophotometry, and viscometry methods. The possibility of binding aminoalkoxybiphelyls in the DNA minor groove has been shown by molecular docking. It has been shown that all 4,4'-dihydroxybiphenyl, benzidine, and 4{(E)-[(4-hydroxyphenyl)imino]methyl}phenol derivatives compete with the conventional DNA ligand for binding sites.