Sokolenko M. Clinical and immunological peculiarities of HIV-associated herpetic infection and optimization of treatment.

The examination of 117 patients with herpetic infections, 65 HIV-infected patients and 67 patients with HIV-associated herpetic infections revealed significant disorders in cellular and humoral immunity: increase in the number of circulating immune complexes, IL-8, IL-10, IL-17 and reduction of IL-12 rate. HIV-associated herpetic infections were accompanied by an inverse correlation between the rates of IL-8, IL-10, IL-17 and CD4+-lymphocytes, and direct correlation between IL-12 rate and CD4+-lymphocytes. In addition to basic antiherpetic therapy cytokine preparation, that contains alloferon, was used; statistically significant it allows to shorten the duration of clinical symptoms, reduce the frequency of relapses and the duration of the first relapse after treatment of herpetic infections in HIV-infected patients. This combination therapy also provides a significant increase in functional activity of mature T-lymphocytes in patients with HIV-negative status, a stop of further decrease in the number of CD4+-lymphocytes at the II clinical stage of HIV infection and normalization of serum levels of IL-8, IL-10, IL-17 and IL-12 in patients with HIV-associated herpetic infections.