Semianiv I. Comprehensive treatment of patients with newly diagnosed pulmonary tuberculosis based on comorbidity of hepato-pancreato-biliary system and gene polymorphisms of glutathione-S-transferase

Subject of the study: primary diagnostic tuberculosis (PDTB); objective - improving the treatment of patients suffering from newly diagnosed pulmonary tuberculosis with concomitant lesions in hepato-pancreato-biliary system and gene polymorphism in the system of xenobiotic detoxification of glutathione-S-transferase; methods of the study - clinical, biochemical, radiographic, microbiological, morphological, histological, genetic, instrumental, statistical; the novelty - installed prevalence of pathology hepato-pankreato-biliary system in patients with pulmonary tuberculosis; studied enzyme gene polymorphism biotransformation of xenobiotics glutathione-S-transferase and morphological changes in the liver pulmonary tuberculosis; the application in the intensive phase of antimycobacterial therapy PDTB lung injectable isoniazid and rifampicin against the background pryomu hepatoprotector arginine glutamate, which improves efficiency criteria for assessing treatment. Field of application - medicine.