Partsevska S. Block copolymers based on poly(ethylene oxide), polycaprolactone and polyacrylamide and their micellar nanocarriers

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0417U003224

Thesis Registration Form

0417U003224.pdf

Applicant for

Specialization

  • 02.00.06 - Хімія високомолекулярних сполук

30-05-2017

Specialized Academic Board

Д 26.001.25

Taras Shevchenko National University of Kyiv

Essay

The thesis includes synthesis, studies of bulk structure and micellization of triblock copolymers with chemically complementary blocks PEO and PAAm and amphiphilic di- and triblock copolymers based on (MO)PEO and PCL. Mechanisms of block copolymers micelles self-assembling in aqueous and aqueous-organic medium were shown and various morphology of micellar structures was established. Based on two types of block copolymers, novel micellar nanocarriers for poorly soluble drugs prednisolon and vitamin E were created and the mechanisms of drugs encapsulation were investigated. The high efficiency, biocompatibility and nontoxicity of created micellar carriers for vitamin E were proved.

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Files

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aref.doc

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dis.doc

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