Hovorova D. Invasive mycoses caused by yeasts fungi of sort of Candida spp. and Cryptococcus spp.: features of clinic, diagnostics and treatment.

Dissertation for the degree of candidate of medical sciences, specialty 14.01.13 - infectious diseases / SI "L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases of NAMS of Ukraine". Frequency and spectrum of mycotic infection (MI) and risk of its development factors are presented in dissertation work, on the basis of inspection of 170 patients of intensive care unit (ICU) infectious profile (IP). It is set that at a primary inspection MI registers 60,71 % of patients, herewith an invasive candidiasis (IC) (44,70 %) prevails considerably, rarer cryptococcosis (Cr) (8,82 %) appears and combination of Cr with a candidiasis (7,06 %). In all cases, invasive mycoses were a mixed infection. There was multifocal colonization of Candida spp. In 81,82 % of cases, with bringing in to the pathological process of a few anatomic areas. The analysis of basic indexes of immunity is conducted at this category of patients. It is shown that CrМЕ (15,88 %) and CaМЕ (3,53 %) belong to the worst casesof МI.High informing and diagnostic value of the system for the exposure of cryptococcal antigen of latex agglutination (LA) test (CALAS®) especially for the patients with HIV-status are presented. The analysis of efficiency and features of antifungal therapy is conducted for patients with invasive mycoses in the conditions of ICU IP, including in the conditions of defeat of the nervous system.