Object of research - metastatic defeat of long limb bones in patients with malignant tumors; the goal is to improve the treatment efficiency and quality of life of patients with metastatic lesions of long limb bones by developing a differentiated approach to the choice of therapeutic tactics; methods - clinical, laboratory, radiological, radiological, experimental morphological, statistical; novelty and results - improved approaches to the diagnostic examination of patients with malignant tumors with suspicion of metastatic bone defeat; methodological principles of distribution of patients with metastatic lesions of long limb bones in clinical groups were developed, which allowed to substantiate clear indications for a certain type of treatment and determined the rational tactics of therapeutic measures; for the first time, based on experimental morphological studies, it has been shown that there is no reaction of the soft tissues surrounding the tumor of the bone and visceral organs on metal-polymer and carbon-carbon materials, which allowed them to be used as an implantation material in the surgical treatment of metastatic bone tumors; improved intraocular regimen cytostatic drugs in the preoperative period, which increased the efficiency of surgical treatment and improved postoperative outcome of treatment and survival of patients; it is proved that application of the developed methods of surgical replacement of the defects of long limb bones in patients with metastatic lesion can improve the quality of life of the patient by preserving the limb and its function, which positively affects the social and psychological adaptation of the patient in the postoperative period; implemented in clinical practice of the Department of Traumatology and Orthopedics and the Department of Surgery, Anesthesiology and Intensive Care Therapy of Postgraduate Education at the National Medical University named after. O. O. Bohomolets, Ministry of Health of Ukraine, Kyiv; Clinical departments of the Institute of Traumatology and Orthopedics of the National Academy of Medical Sciences of Ukraine, Kyiv; Department of Traumatology, Kyiv City Clinical Hospital No. 1; the orthopedic department of the Kyiv City Clinical Hospital No. 12; Department of Traumatology, Center of Orthopedics, Traumatology and Vertebrology, Clinical Hospital "Regional Clinical Hospital" of the Rivne Regional Council; Clinical Department of the Kyiv City Clinical Cancer Center; Clinical Department of the Chernigiv Regional Oncology Center; Hospital of Traumatology Department "Regional Hospital of Intensive Care", Mariupol; Research Institute of Traumatology and Orthopedics of the Donetsk National Medical University of the Ministry of Health of Ukraine, Lyman; Regional Clinical Hospital, Lyman, as well as in the pedagogical process of the Department of Traumatology, Orthopedics and Military Field Surgery of the Donetsk National Medical University of the Ministry of Health of Ukraine, Lyman; the branch of use-treatment and diagnostic process of specialized orthopedic, orthopedic units, clinics, scientific and pedagogical processes of departments of traumatology and orthopedics, oncology and medical educational institutions.
