Fedchishen O. Pathogenic importance of antimicrobial peptides and vitamin D deficiency for diagnosis and treatment of asthma in children

The thesis is devoted to the study of increasing the effectiveness of treatment of children with bronchial asthma on the basis of new scientific data on the pathogenetic role of antimicrobial peptides and vitamin D. Using the complex examination of children with bronchial asthma, the role of the antimicrobial peptide catelicidin LL-37 and 25-hydroxycholecalciferol in the development of the disease and a certain relationship with the duration and severity of bronchial asthma.Based on the results obtained, the nature of the changes in these substances is determined depending on the clinical form, period, severity and level of control of bronchial asthma in children and their effect on the course of the disease. The relationship between the level of the antimicrobial peptide catelicidin LL-37, 25-hydroxycholecalciferol and the markers of the activity of the inflammatory process in bronchial asthma in children was established. As a result of the study, the diagnostic value of individual antimicrobial peptides, in particular cathelicidin LL-37, was established in the progression of the course of bronchial asthma in children and their association with individual immune system indices and the function of external respiration. The possibility of an answer to the treatment of children with bronchial asthma, with various forms of the disease, taking into account the pathogenetic role of the antimicrobial peptide catelicidin LL-37 and 25-hydroxycholecalciferol was studied. A method for diagnosing bronchial asthma in children is proposed by determining the content of the antimicrobial peptide cateicidin LL-37, allows to determine the further tactics of the basic anti-inflammatory treatment and to achieve adequate control.