Kaminskyi O. Adsorption immobilization of cis-dichlorodiammineplatinum and ionic forms of heavy metals by nanostructures of different surface nature

The dissertation investigates the conception of the development of chemical formation of multilevel nanostructures with a hierarchical nanoarchitecture and functions of biomedical nanorobots. The paper determines the properties of nanosized single-domain magnetite (Fe3O4) as a part of magnetic liquid and principles of adsorption immobilization of cis-dichlorodiammineplatinum (ІІ) on the single-domain Fe3O4 surface, pyrogenic SiO2, nanocomposite structures Fe3O4/meso-2,3-dimercaptosuccinic acid (DMSA) and SiO2/DMSA, Fe3O4/hydroxyapatite (HA), Fe3O4/gamma-aminopropyltriethoxysilane (gamma-APS), Fe3O4/polyacrylamide (PAA), сomparative analysis of the results and the establishment of principles of complex extraction of cis-dichlorodiammineplatinum (ІІ) and complexes of precious metals Au3+, Ag+, Cd2+, Pb2+, Ni2+, Zn2+, Cu2+from aqueous liquids. The single-domain magnetite synthesis was conducted with the help of sol - gel method. Methods of electron microscopy revealed that particles of magnetite were characterized by 3 - 23 nm. It is established that the calculations of magnetization curve of magnetic liquid based on the single-domain Fe3O4 within the framework of Langevеn's paramagnetism theory approves with the experimental results under the assumption that the saturation magnetization of magnetite particles depends on their size; a reducing of the saturation magnetization is with the decreasing of diameter d-nanoparticles may be due to the increase of the surface spin subsystem, which makes a contribution to the overall magnetization particles; factual findings make scientific basis of the magnetic granulometry method development and its application for measuring dimensional parameters of complex shell structure magnetosensitive nanocomposites of the core-shell type. A comparative study of the adsorption of cis-dichlorodiammineplatinum (ІІ) by magneto nanostructures with different chemical nature of the surface was held: single-domain nanosized nanocomposites Fe3O4/DMSA, Fe3O4/?-APS, Fe3O4/PAA, Fe3O4/HA; the isotherm and kinetics of the adsorption of the complexes of cis-dichlorodiammineplatinum(II), depending on the chemical nature of the surface of nanostructures were studied; the best adsorption parameters showed Fe3O4/ PAA and Fe3O4/gamma-APS that can be explained by the ability of amino groups to form complexes with ions of platinum; the highest adsorption capacity is observed in nanocomposites Fe3O4/PAA, which may be due to the presence of a developed structure polyacrylamide surface which is appropriate for polymerization method which was used. The adsorption of cis-dichlorodiammineplatinum (II) complexes on the surface of nanosized pyrogenic silica and nanocomposites SiO2/DMSA was investigated; isotherms and kinetic curves are characterized by the saturation and the value of the adsorption capacity and distribution ratio indicate the effect of the chemical nature of the surface adsorption of cis-dichlorodiammineplatinum (ІІ); multistagen nature of hydrolysis cisplatin complexes during its release from the surface of nanostructures in physiological saline is experimentally verified by spectral methods. The value of adsorption capacity saturation of monolayer A (mg/g) of adsorbents due to platinum complexes allow to arrange nanocomposites in such experimental dependence: Fe3O4/PAA> Fe3O4/gamma-APS > Fe3O4/DMSA > SiO2/DMSA > Fe3O4 > SiO2 > Fe3O4/HA.