Kusyak A. Adsorption activity of surface in conception of multilevel nanocomposites with the functions of nanorobots

Magnetosensitive nanocomposites of Fe3O4/SiO2, Fe3O4/TiO2, Fe3O4/Al2O3 and Fe3O4/GA are studied using complex of physical and chemical methods and the peculiarities of their surface structure are found. The adsorption activity of MN synthesized surface (adsorption/desorption processes, adsorption activity dependence on pH and time) regarding the complexes of cis-dichlorodiammineplatinum, doxorubicin, Zn (II), Cd (II) an Pb (II) ions from aqueous solutions is studied. The adsorption process parameters of Zn (II), Cd (II) and Pb (II) for all synthesized samples are established. The capacity of MN synthesized operation in the biological environment (blood plasma) is confirmed experimentally. Ability to use stabilizing agents (DMSO and PEG 2000) to prevent opsonization of MN is tested and proven, MN ability to remove Pb (II) ions from human plasma in sublethal and lethal doses is proven. A promising for practical use technique of adsorption immobilization of cytotoxic drug doxorubicin on the surface of MN Fe3O4/GA is developed. Experimentally confirmed that the magnetosensitive nanocomposites Fe3O4/DR, Fe3O4/SiO2/DR, Fe3O4/TiO2/DR Fe3O4/GA/DR exhibit cytotoxic activity against yeast cells Saccharomyces cerevisiae, using their culture the technique of preclinical control of cytotoxic activity of MN with immobilized DR is perfected. Using an ensemble of Fe3O4 carriers as super paramagnetic probe, Langevin's theory of paramagnetism, the density of nanocomposite components, dimensional parameters of MN Fe3O4/GA/DR shell composed of magnetic fluid are assessed by magnetic measurements. The results may be useful for the development and optimization of new forms of magnetically directed delivery of drugs and adsorbents based on nanocomposites of super paramagnetic core-shell with multilevel nanoarchitectural and to determine and control the dimensional parameters of its components. Performed work develops and complements the concept of chemical design of multilevel nanostructures with a hierarchical nanoarchitecture and functions of biomedical nanorobots.