Bortnik I. Endovascular treatment of patient with cerebral arteriovenous malformations and associated aneurysms

Українська версія

Thesis for the degree of Candidate of Sciences (CSc)

State registration number

0418U000993

Applicant for

Specialization

  • 14.01.05 - Нейрохірургія

18-09-2018

Specialized Academic Board

Д 26.557.01

The State institution "Romodanov neurosurgery institute, National academy of medical sciences of Ukraine"

Essay

The thesis proposes a new scientifically based approach to solve the problem of improvement of AVM and associated aneurysms endovascular treatment results. Pooled scientific data about the nature of clinical manifestations and proposed differentiated tactics of endovascular treatment. We analized the results of a comprehensive survey and endovascular treatment of 117 patients with AVM ? associated aneusrysms, which were treated in SI "Scientific-Practical Center of Endovascular Neuro X-ray surgery NAMS Ukraine" from 2004 to 2017 years. The patients age range between 8-67 years. There were 65 (55,6%) men and 52 (44,4%) women. Endovascular surgical procedures were performed in 106 (90,6%) patients, 11 (9,4%) patients were not operated. One hundred and four (88,9%) patients underwent simultaneous procedures of aneurysms and AVM occlusion. Patients were divided into 5 clinical groups, according to Perata classification: group 1 ? 3 (2,6%) patients with unrelated aneurysms; group 2 12 (10,3%) patients with proximal flow related aneurysms; group 3 - 15 (12,8%) of patients with distal flow related aneurysms; group 4 - 59 (50,4%) patients with intranidal aneurysms; group 5 - 28 (23,9%) patients with multiple aneurysms. Statistical evaluation of hemorrhage and type of aneurysm indicates the presence of a strong correlation, which means the increase the frequency of haemorrhagic manifestations while reducing the distance between the aneurysm and AVM. We proposed angiographic classification of intranidal aneurysms into 3 types: I - arterial intranidal; II - actual intranidal; III - venous intranidal. We discovered that the highest risk of hemorrhage had arterial-intranial aneurysms and absolute risk had multiple aneurysms.The main priority of the treatment of AVM and associated aneusrysms is dealing with aneurysm first, as "hemorrhagic dominant" - the pathology with more aggressive clinical course, during simultaneous AVM embolization. The results of AVM and associated aneusrysms treatment according to Glasgow outcome scale: 5 points - 99 (84,6%) patients 4 points - 12 (10,3%) patients, 3 points - 2 (1,9%) patients (2 not operated), 2 points - 0 (0%), 1 point - 4 (3,4%) (3 not operated) patients.

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