297 patients were examined concerning acute intestinal diseases (AID) of the moderate severity with the evident gastrointestinal syndrome. Among them there were 97 patients with AID caused by the opportunistic microorganisms (OM) and 11 of viral etiology, 189 with salmonellosis (S). The research covered 189 patients with S and 44 healthy persons.
The new approach to solve the scientific problem, to treat the gastrointestinal form of S is substantiated that presupposes the addition of the combined probiotic (CP) to the basis and antibacterial therapy, or the omission of the antibacterial medicines from the therapy with the use of a CP. The way to treat the gastrointestinal form of S with the use of CP (live lyophilized Saccharomyces boulardii 0,325×109; spores of Lactobacillus sporogenes (Bacillus coagulans) 0,325×109; live lyophilized Lactobacillus rhamnosus 0,325×109; live lyophilized Bifidobacterium longum 0,325×109) is worked out to decrease the level endogenous intoxication, correct disbiotic disorders and reduce the period of convalescence. The supplement “Indices of Endogenous Intoxication” for the mobile operation system Android that enables the quick calculation of the integrative indices through clinical blood test indicators and the supplement “The Degree of Salmonellosis Severity” to determine the degree of S severity are elaborated.
The leading etiological factor for the patients with S is S. enterіtіdіs (74,10 %) that more often causes the disease of women (1,3 times) unlike S. typhimurium that is more typical of men (2,4 times), p < 0,01. S. enterіtіdіs is a pathogen of S for younger persons more than S. typhimurium (p < 0,05). The basic probable factors of S contagion for men that are more often than for women are poultry eggs (1,7 times), dairy products (1,1 times), and for women that are more often than for men are fish products (1,4 times), confectionary products (2,3 times), p < 0,05. When S is caused by S. typhimurium, the contagion factors are more often eggs (1,2 times) and fish products (1,4 times), and when S. enteritidis, these are vegetables (1,9 times), p < 0,05.The use of CP for the basis treatment of the patients with S both with the antibacterial therapy (Group CIII) and without it (Group CII) accelerates the normalization of clinical and laboratory parameters. The symptoms of the patients from Group CIII disappeared 1,2-1,6 times faster, from Group CII 1,1-1,6 times faster than those of the patients from Group CI (treatment without CP) and CIV (treatment with other probiotics) (р < 0,05-0,001). It is found out at the moment of treatment completion that the patients from Groups CII and CIII, unlike the examined patients of groups CI and CIV, have the normalized number of bifidobacterium, lactobacilli and the general quantity of coli bacilli; haemolysing microorganisms disappear from the patients of Group CIII; the patients from Groups CII and CIII have fewer OM and Candida fungi (р < 0,05).
