Bilyuk A. Evaluation of antitumor, anti-metastatic and biochemical parameters of newly synthesized n, π-chelate complexes Pd2+ and Pt2+ with N-allythiourea

The dissertation is devoted to the study of antiproliferative, proapoptic effects and activity of key enzymes that cause the formation of drug resistance under the influence of the newly synthesized n, π-chelate complexes Pd2+ and Pt2+ with N-allythiourea using tumor cell model systems in vitro and in vivo. The formation of a tumor and the resettlement of metastatic cells by the circulatory and lymphatic systems are closely linked to metabolic reprogramming. The emergence of drug resistance of tumor cells to currently existing drugs, in particular cisplatin, is associated with biochemical anaplasia, which includes various aspects of biochemical disorders, including the prevalence of glycolytic over mitochondrial respiration and the activation of antioxidant defense enzymes such as gamaglutamintranspeptidase. To overcome the disadvantages of therapy associated with the emergence of resistance to cisplatin, used as ligands in the synthesis of cisplatin analogues, N-allyl substituted derivatives of thiourea belonging to chelate ligands with "soft" (according to the Pearson classification) donor groups, or used complexes with other transition metal Pd (II) having lower toxicity and cost of compounds and are promising objects for the search of new potential antitumor drugs.