Shlapa Y. Synthesis and properties of nanosized particles and core/shell structures based on (La,Sr)MnO3

Weakly agglomerated (La,Sr)MnO3 nanoparticles were synthesized via different methods (precipitation from non-aqueous media, precipitation from reversal microemulsions and sol-gel method). It was established that (La,Sr)MnO3 nanoparticles synthesized via sol-gel method had better magnetic parameters and higher heating efficiency in an alternating magnetic field. Core/shell structures based on synthesized nanoparticles with the inorganic and organic shell were developed. It was shown that such structures heated up in an alternating magnetic field to necessary temperatures and they are promising for magnetic hyperthermia. It was firstly investigated the possibility of fine-tuning the Curie point in the narrow temperature range by the additional substitutions in manganese (Mn – Fe) and lanthanum sub-lattices (La – Nd, Sm) and possibility of automatic controlling the heating temperature of magnetic nanoparticles near 43 – 45°C. Results of biomedical studies of magnetic fluids based on (La,Sr)MnO3 in vitro and in vivo showed the possibility to use the synthesized ferromagnetic nanoparticles as the inducers of magnetic hyperthermia.