Kurinna O. Improvement of the diagnostics and prediction of the course of non-alcoholic fatty liver disease associated with obesity by determining the clinical and pathogenetic role of proinflammatory activation

The dissertation is devoted to the improvement of the diagnostics and prediction of the course of non-alcoholic fatty liver disease (NAFLD) associated with obesity through the development of a model for assessing the risk of disease’s progression and pathogenetic justification of a therapy. The peculiarities of the clinical course of NAFLD associated with obesity, which were manifested as a decrease in patients’ physical endurance by cycle ergometry, disorders of carbohydrate and lipid metabolism with development of insulin resistance and proatherogenic dyslipidemia, were specified. The role of proinflammatory activation in the development and progression of NAFLD associated with obesity were specified. The main predictors of fatty liver progression in patients with сoncomitant obesity were determined. The advisability of the prescription of an active complex non-drug therapy with a duration of at least 24 weeks (lifestyle modification, weight reduction, adjustment of the diet composition and regimen, an expansion of physical activity) aimed to steatosis reduction, correction of metabolic disorders and inhibition intensity of proinflammatory activation in patients with NAFLD associated with obesity was proved.