Object: age-related macular degeneration, dry and exudative forms. Purpuse: increase of treatment efficacy of age-related macular degeneration (AMD) using low-energy impulse chromatic LED therapy of green (505 nm), red (625 nm), and infra-red (940 nm) diapasons (low-energy LED therapy, LLT) together with drug therapy of dry AMD and following the angiogenic therapy of exsudative AMD. Methods: visometry, tonometry, static and dynamic perimetry, biomicroscopy, ophthalmoscopy, ophthalmochromoscopy, heterochromatic flick-photometry, Amslera cattle research, color photographing of the fundus, fluorescence angiography, optical coherent tomography, statistical methods. Electronic perimeter "Topcon", perimeter T-3, direct ophthalmoscope BMO, densitometr "Maculux praxis", retinal camera "Topcon", optical coherent tomography "Cirrus HD-OCT", model 5000. The scientific novelty is that the author was the first to investigate the increase of macular pigment concentration in the macular zone of retina due to the influence of low-energy impulse chromatic LED therapy of green (505 nm), red (625 nm), and infra-red (940 nm) diapasons together with drug therapy in dry AMD patients, the data being suggested by the increase of macular pigment optical density from 0,249 U up to 0,348 U (by 55,8%) in 12 months of the follow-up. The author completes the scientific data concerning functional central vision parameter following the new complex AMD treatment suggested by vision acuity stabilization in patient group with low sight and dry form from 28,4 up to 28,7 signs, increase of vision acuity in patients with low sight and exudative form by 2,5 signs, while in high vision acuity groups the increase of vision acuity for both AMD forms became increased by 5,2 signs and 2,4 ones, respectively, in 12 months of the follow-up. Practical application of the results obtained. A new complex approach intended for age-related macular degeneration is proposed using low-energy impulse chromatic LED radiation of green (505 nm), red (625 nm), and infra-red (940 nm) diapasons with the duration of radiation impulse 10 ms, impulse frequency 30 ms, exposition 5 min, energy 2х10-6J, and power density on cornea 0.83 mV/cm2 during 10 days (a séance per day) together with drug therapy for dry AMD and after anti-angiogenic therapy for exudative form. The courses of low-energy LED therapy are recommended to be carried out with 6 months interval. Following the dry AMD complex treatment, the stabilization of macula morphological structure is seen, namely of pigment epithelium local defect (88,4 %), pigment epithelium atrophy (91,1 %), pigment epithelium hyperplasia (89,0 %), druse quantity and size (86,3 %), these data being confirmed by the optical coherent tomography (OCT) examination in 12 months of the follow-up. The author reveals also the stabilization of macula morphological structure following the exudative AMD complex treatment, namely of neuroepithelium cystic edema (88,1 %), neuroepithelium diffuse edema (61,2 %), neuroepithelium detachment (91,1 %), pigment epithelium detachment (85,1 %), sub-retinal neovascular membrane (58,2 %), these data being confirmed by the OCT examination in 12 months of the follow-up. The dissertation provides additional information concerning morphometric characters of macula microstructure following the complex treatment in persons with exudative AMD consisting in the stabilization of retina thickness parameter in fovea during 12 months of the follow-up comparing to the monotherapy with worsened parameter having increased by 38,9 %. Low-energy pulsed chromatic LED therapy of green (505 nm), red (625 nm) and infrared (940 nm) ranges should be performed in the complex treatment of dry and exudative forms of age-related degeneration of the macula. This technique is implemented in the ophthalmologic department of the Kyiv City Clinical Hospital # 9, the ophthalmologic department of the Kyiv City Clinical Hospital # 8, the ophthalmologic office of the branch # 3 of the "Consultative Diagnostic Center" of the municipal nonprofit enterprise of the Shevchenkivskyi district of Kyiv. The results of the study were introduced into the educational process at the Department of Ophthalmology of the National Medical University named after Acad. O.O. Bogomolets. Scope of application - medicine, ophthalmology.
